2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W127458
    Tin(II) palmitate 35104-88-2 98%
    Tin(II) palmitate (Hexadecanoic acid, tin(2+) salt) is a long-chain saturated fatty acid commonly found in animals and plants. Tin(II) palmitate can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP) in mouse granular cells. Tin(II) palmitate can be used to establish a model of cellular steatosis.
    Tin(II) palmitate
  • HY-W140208
    3-Phenylthiophene 2404-87-7 98%
    3-Phenylthiophene (Compound 25) is a CYP2A6 inhibitor with a Ki value of 3.3 μM. The Ki values for CYP2E1, CYP2B6, CYP2C9, and CYP2C19 are 9.7, 14, 112, and 107 μM respectively. It shows no significant inhibition on CYP3A4 and CYP2D6. 3-Phenylthiophene can be used in smoking cessation research.
    3-Phenylthiophene
  • HY-W150182
    p-Cymen-8-ol 1197-01-9 98%
    p-Cymen-8-ol is an alcohol. p-Cymen-8-ol can be used to make essential oils. Essential oils containing p-Cymen-8-ol exhibit immunomodulatory activity. p-Cymen-8-ol, when used in combination with other substances to make essential oils, exerts an anxiolytic-like effect and reduces hepatic lipid peroxidation levels in ICR mice. p-Cymen-8-ol may be used in research on anxiolytic and other neurological and immune system disorders.
    p-Cymen-8-ol
  • HY-W152736
    2-Methyl-5-acetylphenol 33414-49-2
    2-Methyl-5-acetylphenol is a hydroxylated methylacetophenone that exists in the aerial parts of Cannabis sativa subsp. sativa. 2-Methyl-5-acetylphenol exhibits strong binding affinity to HIPK2. 2-Methyl-5-acetylphenol cannot reverse MPP+ (1-methyl-4-phenyl-pyridinium ion)-induced neuronal cytotoxicity. 2-Methyl-5-acetylphenol can be used for Parkinson's disease research.
    2-Methyl-5-acetylphenol
  • HY-W158948
    6-Fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole 180161-14-2 98%
    6-Fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole is a ORL-1 receptor modulator. 6-Fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole regulates downstream pathways associated with nociception, cognition and physiological processes. 6-Fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole is used in the research of central nervous system diseases and pain-related disorders including anxiety, depression, Alzheimer's disease and attention deficit disorder.
    6-Fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
  • HY-W165085
    1,10-Bis(pyridinium)decane 6266-40-6 99.66%
    1,10-Bis(pyridinium)decane (Decamethylenebispyridinium dibromide) is an acetylcholinesterase (AChE) inhibitor with an IC50 of 25.8 nM. 1,10-Bis(pyridinium)decane acts as a bis-quaternary ligand that bridges the enzyme's catalytic site and peripheral site via its two pyridinium groups. 1,10-Bis(pyridinium)decane can be used for the research of alzheimer's disease.
    1,10-Bis(pyridinium)decane
  • HY-W171071
    Phenylethynylcarbinol carbamate 3567-38-2 98%
    Phenylethynylcarbinol carbamate is a agent used for neurology disease. Phenylethynylcarbinol carbamate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Phenylethynylcarbinol carbamate
  • HY-W186242
    PDE4-IN-16 223500-15-0 98.84%
    PDE4-IN-16 (compound 27) is a PDE4 inhibitor with an IC50 value of 3.61 μM. PDE4-IN-16 can be used for the research of inflammatory diseases and central nervous system (CNS) disorders involving elevated levels of cytokines.
    PDE4-IN-16
  • HY-W192276
    (±)-Desisopropylpropranolol 20862-11-7 98%
    (±)-Desisopropylpropranolol (N-Desisopropylpropranolol) is a metabolite of Propranolol (HY-B0573B). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Kis of 1.8 nM and 0.8 nM, respectively. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.
    (±)-Desisopropylpropranolol
  • HY-W197393
    3,6-Diaminoacridine sulfate 553-30-0 98%
    Proflavine sulfate is a multifunctional acridine compound. 3,6-Diaminoacridine sulfate is an acridine dye and also a DNA inserter. Proflavine sulfate is a potent broad-spectrum antibacterial agent, and its mechanism is to insert into bacterial DNA, interfering with replication and transcription, causing bacterial lysis. 3,6-Diaminoacridine sulfate is a Kir3.2 potassium channel blocker and can be used to study the neurological phenotype of Down syndrome. 3,6-Diaminoacridine sulfate can penetrate the stratum corneum of the skin and accumulate in the cell nucleus and long-term exposure may induce skin cancer or other malignant tumors.
    3,6-Diaminoacridine sulfate
  • HY-W201842
    Octamylamine 502-59-0 98%
    Octamylamine is an anticholinergic and antispasmodic agent.
    Octamylamine
  • HY-W205529
    RO 16-6491 free base 87235-61-8 98%
    RO 16-6491 Free base is a selective, reversible inhibitor of monoamine oxidase type B (MAO-B), exhibiting high affinity and specificity for binding sites in human frontal cortex mitochondria and platelet membranes. RO 16-6491 demonstrates a fast dissociation of bound radioactivity at 20 degrees C, indicating its dynamic binding properties. RO 16-6491 also acts as a substrate for MAO-B, suggesting that its oxidation may produce a stable intermediate responsible for its potent inhibitory effects. RO 16-6491 serves as an excellent radioligand probe for investigating the regional tissue distribution of MAO-B in various physiological and pathological states.
    RO 16-6491 free base
  • HY-W207699
    MAO-B-IN-46 27052-20-6 98%
    MAO-B-IN-46 (Compound 16) is a selective hMAO-B inhibitor (IC50: 26.8 nM), with weak activity against hMAO-A (IC50: 7.2054 μM). MAO-B-IN-46 (Compound 8) also acts as an α-amylase inhibitor (IC50: 19.46 μM). MAO-B-IN-46 exhibits certain neuroprotective effects and shows no significant toxicity to human gingival fibroblasts and SH-SY5Y cells. Additionally, MAO-B-IN-46 can scavenge DPPH and ABTS free radicals, with IC50 values of 17.86 μM and 17.71 μM, respectively. MAO-B-IN-46 can be used in the research of neurodegenerative diseases such as Parkinson's disease, diabetes, and diseases related to oxidative stress resistance.
    MAO-B-IN-46
  • HY-W223348
    Org-9768 759424-59-4 98%
    Org-9768 (Compound (2-methyl-2,3-dihydro-1H-inden-2-yl)methanamine) is a drug intermediate for synthesizing the mitochondrial permeability transition pore (mPTP) inhibitor. Org-9768 can be used for the researches of neurological and cardiovascular disease, such as Parkinson's disease.
    Org-9768
  • HY-W230975
    (E/Z)-Piperine 7780-20-3 98.91%
    (E/Z)-Piperine ((E/Z)-Bioperine) is an alkaloid with a pungent property. (E/Z)-Piperine shows anti-inflammation, immunomodulatory and anti-cancer, antispasmodic and anti-secretory effects. (E/Z)-Piperine demonstrates significant neuroprotective effect in Alzheimer’s disease and Parkinson’s disease.
    (E/Z)-Piperine
  • HY-W235067
    N,N-Dimethyldodecylamine 112-18-5 98.42%
    N,N-Dimethyldodecylamine is a dynamin I inhibitor. N,N-Dimethyldodecylamine has an IC50 value of 14.79 μM for GTPase activity of dynamin I. N,N-Dimethyldodecylamine can be used in the research of diseases associated with endocytic defects, such as Alzheimer's disease and Huntington's disease.
    N,N-Dimethyldodecylamine
  • HY-W263279
    (E)-Guanabenz 60329-03-5 98%
    (E)-Guanabenz ((E)-Wy-8678) is an orally active central α2-adrenoceptor agonist. (E)-Guanabenz has antihypertensive activity, acts via stimulating central α2-adrenoceptors, and reducing net sympathetic outflow into the periphery. (E)-Guanabenz also directly binds to and inhibits GADD34, and has neuroprotective activity. (E)-Guanabenz can be used for researching hypertension and Parkinson disease.
    (E)-Guanabenz
  • HY-W264038
    4-Fluorohippuric acid 366-79-0 98%
    4-Fluorohippuric acid is a major metabolite of flupirtine with research potential against pain and epilepsy.
    4-Fluorohippuric acid
  • HY-W265961
    Squoxin 1096-84-0 99.75%
    Squoxin (ST1859) is an antiamyloid agent that specifically binds to Aβ1-42 and prevents the aggregation and fibril formation of Aβ. Squoxin crosses the blood-brain barrier (BBB) and has anthelmintic activity and anti-inflammatory properties.
    Squoxin
  • HY-W269511
    NW-1689 405-85-6 99.54%
    NW-1689 is a process-related impurity of safinamide mesilate (SAFM). SAFM can be used for the study of Parkinson's disease (PD). It is a highly selective and reversible inhibitor of monoamine oxidase-B (MAO-B) and also blocks sodium channels and N-type calcium channels. These effects of SAFM help reduce the breakdown of dopamine and inhibit the release of glutamate. NW-1689 has a similar chemical structure to SAFM and has some similar pharmacological effects as SAFM, and can be used in Parkinson's disease research.
    NW-1689
Cat. No. Product Name / Synonyms Application Reactivity